The Journal “Toksikologicheskiy vestnik” (Toxicological Review)


У вас не оплачено получение pdf-версии данного журнала.

Jan–Feb, 2016
# 1


THE SECONDARY DAMAGE TO BIOLOGICAL OBJECTS IN REMOTE PERIOD (100 DAYS) AFTER THE GAS WEAPON APPLICATION
Authors: Podosinovikova N. P. , Alexsandrova M. L. , Kacherovich P. A. , Lapina N. V.

The objective of the present research was a clarification of possibility of secondary damage to biological objects in a remote period (100 days) after application of irritants chloracetophenone, ortochlorbenzylidenmalonodinitrile, dibenzoxazepine and morpholide of pelargonic acid as components of the gas weapon. In a model experiment, irritants were applied to a fabric target in a quantity corresponding to an estimated concentration arising at the dispersion of a gas spray from a distance of 0.5 meters and 1.5 meters. Data are submitted on a remaining irritant in the target object after 100 days at an open way of storage The toxicity assessment of irritants to a biological test object zoohydrobiont Daphnia magna Straus was carried out. The concentration of irritants extracted from the target object were compared to their toxicity to Daphnia. It was established that chloracetophenone, dibenzoxazepine, and pelargonic acid morphodine preserved their activity and possibility to affect an ecosystem more than 100 days after their application . At the maximum extraction from the target, ortokhlorbenzylidenmalonodinitrile does not preserve its biological activity 100 days after application.

Keywords: irritant, ability preservation in targets, bio objects secondary damage, Daphnia magna, bio testing


PRECLINICAL TOXICOLOGICAL STUDIES OF ANTIMICROBIAL DRUG IN SEXUALLY IMMATURE ANIMALS
Authors: Bortnikova V. V. , Krepkova L. V. , Guskova T. A.

A preclinical safety study of an antimicrobial phyto preparation «Sanguiritrin» in immature animals was carried out. It is shown that at a single intraperitoneal administration of«Sanguiritrin» to newborn baby rats and rats of 3 weeks of age, a mean lethal dose was set at a level of 22.0 ± 2.5 mg/kg and 17.6 ± 1.5 mg/kg (male), 18.0 ± 2,0 mg/kg (female), respectively. Infant rats are less sensitive to the «Sanguiritrin» toxic effect as compared to sexually mature rats (LD50 10.0-12.0 mg/kg). A long-term peroral administration (2 months) of the substance «Sanguiritrin» in a dose of 0.5 mg/kg did not have a damaging effect on 3 weeks of age rats major body organs and systems. The intake of «Sanguiritrin» in infant rats in a dose of 5 mg/kg significantly decreased their body weight and disturbed renal excretory function. Application of 0.2% alcohol solution and 1% liniment «Sanguiritrin» to the skin of newborn baby rats and 3 weeks of age rats under conditions of a chronic experiment showed a good tolerability, absence of local irritating action and undesirable toxic effects.

Keywords: preclinical toxicology studies, , 0.2% alcohol solution and 1% liniment, 3 weeks of age rats and infant rats


TTOXICOLOGICAL EVALUATION OF COMBINATION OF AMLODIPINE CALCIUM CHANNELS BLOCKER WITH ANGIOTENSIN RECEPTOR BLOCKERS
Authors: Avdeeva O. I. , Makarova M. N. , Makarenko I. E. , Burenkov P. V. , Shubina M. G. , Kashkin V. A.

The article summarizes experimental data on toxicological interactions of blocker of amplodipine slow calcium channels with angiotensin II (AT1 subtype) receptors blockers (valsartan and losartan). Toxicity studies were performed in outbred rats after a single intragastric administration in doses permitting to estimate lethal doses for the objects under investigation (amlodipine, valsartan, losartan, amlodipine+ losartan 1:10, amlodipine+ losartan 1:20, amlodipine + valsartan 1:16, amlodipine + valsartan 1:32). Based on the research outcome, the possibility of different types of toxicological interaction is shown between representatives of classes of slow calcium channels blockers and angiotensin II receptors blockers: from potentiation of toxic effects to the antagonism in relation to toxicity. Identified toxicological interactions in fixed combinations depend on the proportion of active ingredients in the combination, as well as on modes of action features and pharmacokinetics of each active ingredient.

Keywords: antihypertensive preparations, blockers of slow calcium channels, angiotensin receptors blockers, toxicological interaction, preclinical studies, acute toxicity in rats


JUSTIFICATION OF DIAZOLINE PERMISSIBLE LEVELS IN OCCUPATIONAL AIR IN CHEMICAL AND PHARMACEUTICAL INDUSTRIES
Authors: Kuzminov B. P. , Zazuljak T. S. , Turkina V. A. , Breydak A. A. , Alechina T. A.

The toxicological assessment of diazoline, the first- generation antihistaminic preparation, was carried out together with justification of the hygiene standard for permissible content ( (Tentative Safe Exposure LevelTSEL) of occupational air in production premises. It was found out that according to acute oral toxicity criterion, Diazoline refers to low hazardous substances. In the clinical picture of acute and sub-chronic intoxication, CNS involvement prevails. Diazolin has a weak local irritant effect in case of contact with mucous membranes, shows a strong cumulative activity. In case of intracutaneous sensitization, it influences indicators of the cellular and humoral component of innate and acquired immunity. TSEL of diazoline in occupational air is 1.0 mg/m .

Keywords: diazoline, toxicological assessment, hygienic standard, occupational air


TOXICITY EVALUATION OF SAFETY OF LIOPHILIZATES USED FOR FORMULATION OF THE RADIOPHARMACEUTICAL PREPARATION 68Ga-CITRATE IN EXPERIMENT IN RODENTS
Authors: Lunev A. S. , Petrosova K. A. , Zhukova M. V. , Ternovskaya K. E. , Klementyeva O. E. , Lysenko N. P.

Toxicity effects of «Cigalin» and «Ferocit» lyophilizates used for formulation of the radiopharmaceutical preparation 68Ga-citrate were studied in animal organisms (rats, mice). Good tolerability, absence of pronounced intoxication symptoms, allergenic effects and animal deaths were noted in experiments using a recommended clinic dose of lyophilizates. «Cigalin» didn’t produce toxicity effects influencing on statistically significant changes in blood main hematological and biochemical parameters. Similar changes in case of «Ferocit» used in multiple doses were functionally reversible. The results permit to characterize 68Ga-citrate as safe for clinical applications in radionuclide diagnostics for PET imaging of inflammation and infection.

Keywords: Cigalin, Ferocit, 68Ga-citrate, acute toxicity, chronic toxicity, allergenic effect, safety


CLINICAL OBSERVATION OF APATIENT -DRUG COURIER WITH ACUTE POISONING BY HEROIN
Authors: Shilov V. V. , Lukin V. A. , Savello V. E. , Antonova A. M. , Pivovarova L. P. , Osipova I. V. , Rikova A. V. , Gaiduk S. S.

A clinical observation of a patient, a drug courier. smuggling heroin in containers in gastric cavity is described. He was admitted to a multi-field hospital in consequence of acute poisoning. The acute poisoning resulted from a spontaneous violation of the container and outpouring of its content into the gastric cavity. At hospital, diagnostics and a combined treatment including surgical intervention and detoxification were carried out. Results of clinical, laboratory and instrumental investigations as well as treatment outcome are reported.

Keywords: heroin, systemic inflammation, surgical treatment


THE USE OF EXPERIMENTAL TOXICOLOGICAL DATA FOR EVALUATION OF THE STATE OF NATURAL POPULATIONS OF SMALL MAMMALS
Authors: Besel V. S. , Mukhacheva S. V.

An attempt was made to estimate the dimension of direct toxic effects of exposure to Cd on the basis of researches on reproductive parameters in small mammals in natural populations ( on the example of red-backed vole) inhabiting localities of large-scale non-ferrous metal plants and comparison of results obtained with outcome of toxicological experiments ( chronic exposure of female rats to Cd) ). It was expected that at the existing pollution levels, embryonic losses caused by direct toxic effect of Cd shouldn’t exceed 7%; however actual losses significantly exceeded extrapolation results. Distinctions observed are caused by impact of external and internal factors influencing reproductive potential on fulfillment of reproduction of animals in natural populations.

Keywords: pollution of the environment, cadmium, natural populations, red -backed vole, embryonic losses, toxicological experiment


THE EFFECT OF LANTHANUM ON BIOLOGICAL PARAMETERS OF CRUSTACEANS CERIODAPHNIA AFFINIS LILLJEBORG IN CHRONIC EXPERIMENTS
Authors: Lozhkina R. A. , Tomilina I. I.

The effect of lethal and sub-lethal concentrations of lanthanum on the survival, growth and reproductive parameters of cladoceran Ceriodaphnia affinis in acute and chronic experiments are presented.

Keywords: rare earth elements, lanthanum, toxicity, Ceriodaphnia


Issues

2018:

Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2017:

Cover of Toxical Review Magazine # 6 '2017 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2017 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 2 '2017 Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 1 '2017 Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2016:

Cover of Toxical Review Magazine # 6 '2016 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2016 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2015:

Cover of Toxical Review Magazine # 6 '2015 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2015 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2015 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2015 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2015 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2015 Jan–Feb: # 1download pdf
 

2014:

Cover of Toxical Review Magazine # 6 '2014 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2014 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2014 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2014 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2014 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2014 Jan–Feb: # 1download pdf
 

2013:

Cover of Toxical Review Magazine # 6 '2013 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2013 Jul–Aug: # 5download pdf / Cover of Toxical Review Magazine # 4 '2013 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2013 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2013 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2013 Jan–Feb: # 1download pdf
 

2012:

Cover of Toxical Review Magazine # 6 '2012 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2012 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2012 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2012 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2012 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2012 Jan–Feb: # 1download pdf
 

2011:

Cover of Toxical Review Magazine # 6 '2011 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2011 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2011 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2011 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2011 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2011 Jan–Feb: # 1download pdf
 

2010:

Cover of Toxical Review Magazine # 6 '2010 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2010 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2010 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2010 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2010 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2010 Jan–Feb: # 1download pdf
 

2009:

Cover of Toxical Review Magazine # 6 '2009 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2009 Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2008:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2007:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2006:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2005:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2004:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2003:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2002:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2001:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2000:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1999:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1998:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu
 

1997:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1996:

Nov–Dec: # 6download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1995:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1994:

Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1993:

May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu


Magazine Founder: FBEPH “Russian Register of Potentially Hazardous Chemical and Biological Substances”