The Journal “Toksikologicheskiy vestnik” (Toxicological Review)

pdf
Download PDF-version file for magazine # 1 '2015.

Jan–Feb, 2015
# 1


TOXICOLOGICAL PARADOXES IN MODERN NARCOLOGY
Authors: Golovko A. I. , Sofronov G. A. , Sofronov A. G.

The need for an interdisciplinary approach to the examination of the chemicals-related addictive disorders problem is discussed. It is emphasized that the exaggeration of the role of any scientific vector cannot contribute to the progress in this area of biology and medicine. It is shown on the example of heroin and ethanol that the study of their toxicokinetics and toxicodynamics is far from being completed. That complicates the understanding of the drug addiction and alcoholism development mechanisms. This situation is denoted as one of the paradoxes in modern narcology. Another paradox is examined in connection with the «dose- effect» relationship.. It is shown that the neurochemical pattern, which accompanies exposures to psycho-active substances, can be substantially modified with the procedure for narcotization (alcoholization). A similar uncertainty can require the standardization of some studies in narcology.

Keywords: toxicology, narcology, neurochemistry, toxicokinetics, toxicodynamics


The role of bio-prevention in the framework of managing occupational and environmental chemical risks to population health
Authors: Katsnelson B. A. , Privalova L. I. , Gurvich V. B. , Kuzmin S. V. , Kireyeva E. P. , Minigalieva I. A. , Sutunkova M. P. , Loginova N. V. , Malykh O. L. , Yarushin S. V. , Soloboyeva J. I.

Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace air, reliably safe low exposure levels are technically unattainable or presumably nonexistent. Further to decreasing harmful exposures to the lowest possible levels, the «biological prophylaxis» aims to enhance host’s protective mechanisms. In over 30 years in animal experiments modeling isolated or combined chronic or sub-chronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nano silver, nano copper, formaldehyde, phenol, naphthalene, benzo(a)pyrene, were tested so-called «bio-prophylactic complexes» (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals. Most of these BPCs were then subjected to controlled field trials involving restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations.

Keywords: chemical substance, toxicity, biological prophylaxis


Comparative assessment of investigations into toxic properties of nanomaterials in vivo and in vitro experiments
Authors: Guskova O. A. , Zavyalov N. V. , Skvorcova E. L. , Khamidulina Kh. Kh.

The article presents results of studies on general toxic and irritant action of nanoscale particles of silver, zinc and titanium dioxide in experiments on animals and alternative models ( livestock sperm, Ecolum bacteria and vessels of chick embryo chorioallantoic membrane). Efficiency of using high sensitive alternative models is substantiated for screening assessment of general toxic and irritant action at the preliminary stage of general toxicological and irritant action investigations into nanoscale products .

Keywords: alternative toxicological models, nanoscale particles, livestock sperm, Ecolum bacteria, chick embryo chorioallantoic membrane


Assessment methods of embryotropic action of bio insecticides in experiments
Authors: Orlenkovich L. N. , Remez I. M.

The impact of bio-insecticides Boverin, Entomophthora and Lepidicide on cellular and sub-cellular immune effectors elements in rat fetuses was investigated. Preparations immunotoxic effect on embryos at the cellular and sub-cellular levels was found out.

Keywords: bio-insecticides, embryo, immunotoxicity, embryotropic effect


Transgenerational effects of vinyl chloride
Authors: Kapustina E. A.

The impact of vinyl chloride (inhalation exposure at a mean concentration of 1947 mg/m3 during 5 weeks) on the offspring of exposed male rats and intact female rats was studied. The examination of sexually mature offspring included studying behavior in the open field and DNA damage investigation using brain homogenate with DNAcomet assay. It is revealed an increased orienting-exploratory behavior and decrease in the locomotor activity as well as increased DNA damage in the nervous tissue cells as compared with the control animals group .

Keywords: vinyl chloride, white rats, offspring, behavior, DNA damage


EXPERIMENTAL STUDY OF ALLERGENIC PROPERTIES AND IMMUNOTOXICICITY OF THE DRUG OSCILLOCOCCINUM
Authors: Kovalenko L. P. , Tallerova A. V. , Kuznetsova O. S. , Lapitskaya A. S.

Allergenicity and immunotoxicity of oscillococcinum preparation was experimentally studied. Immunization of guinea pigs with oscillococcinum in doses of 100 mg/kg and 500 mg/kg according to a standard scheme or mixed with complete Freund’s adjuvant ( CFA) did not provoke a systemic anaphylactic reactions or delayed allergenic reactions in animals. A single administration of oscillococcinum per os in doses of 100 mg/kg and 500 mg/kg to CBA strain mice did not cause significant changes in comparison with the control in the inflammation response to concanavalin A (Con.A). To assess oscillococcinum immunotoxic properties, the preparation was perorally administrated to mice in doses of 100 mg/kg and 500 mg/kg for 14 days. Delivery of oscillococcinum in the dose of 500 mg/kg to F1 mice resulted in an authentic increase by 25.1% of thymus mass index. In F1 hybrid mice (CBA x C57BL/6), a course delivery of oscillococcinum induced an expressed increase of peritoneal macrophage phagocytic activity , in C57BL/6 strain mice it significantly stimulated humoral immune response . Thus, oscillococcinum in the dose range investigated does not produce allergenic and immunotoxic action, stimulates macrophage phagocytic activity and humoral response which could be considered one of the most important mechanisms of the preparation action used to cure flu and other acute respiratory viral infections.

Keywords: oscillococcinum preparation, systemic anaphylactic reaction, delayed hypersensitivity, inflammation response to concanavalin A, phagocythosis, hemi luminescence, cellular immune response, immunotoxicity


CORRECTION BY TAUCIN OF LIVER METABOLIN AND FUNCTIONAL LIVER DISTURBANCES IN RATS INROXICATED WITH PARACETAMOL
Authors: Pashko A. U. , Borisenok O. A. , Bushma M. I.

The combination of taurine (50 g/mole, 6.25g) with zinc diaspartate (1 g/mole, 0.35g) named «taucine-50», administrated in the rat stomach (0.50 g/kg over 10 days )increases the paracetamol-inhibited (administrated in the stomach 2.50 g/kg over 5 days) activity of succinate dehydrogenase, lactate dehydrogenase (LDH), nicotinamine adenine nucleotide – dehydrogenase (NADH) and acidic phosphatase (ACPH) in the rat liver and decreases in plasma an increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AspAT) and alkaline phosphatase (ALP) as well as elevated content of total bilirubin, its conjugated forms and cholesterol. Hepatoprotective effect of «taucin-20» (0.5 g/kg/day) is less pronounced.

Keywords: rats, paracetamol, hepatotoxic action, combination of taurine with zinc diaspartate, hepatoprotective action


MATERIALS FOR SUBSTANTIATION OF HYGIENIC STANDARDS FOR BIS (TRIPHENYLSILYL)CHROMATE IN VARIOUS ENVIRONMENTAL MEDIA
Authors: Bidevkina M. V. , Ivanov N. G. , Guglja E. B. , Skrjabina Je. G. , Sheina N. I.

In experiments on white rats, the main toxicometric parameters of bis(triphenylsilyl) chromate were established at single and repeated stomach and intraperitoneal administration. The character of the biological action of bis(triphenylsilyl) chromate with different delivery paths into the organism and levels of effective doses/concentrations are analogous to those of hexavalent chromium compounds. Based on these conclusions, TLV/TWA (Threshold limit value/time-weighted average)) of bis(triphenylsilyl) chromate in occupational air, tentative safe exposure level (TSEL) in atmospheric air of residential settings, tentative permissible levels (TPL) in water of water reservoirs were substantiated and approved at the level of magnitudes adopted for hexavalent chromium compounds in RF.

Keywords: hygienic regulation, hexavalent chromium, toxicity, white rats, kidneys, alveolar macrophages


URGENT ISSUES OF CURRENT TOXICOLOGY. MATERIALS OF THE 50TH CONGRESS OF THE EUROPEAN SOCIETIES OF TOXICOLOGY-EUROTOX 2014
Authors: Rakitskii V. N.

Perspective trends in advancing modern toxicology are the development of alternative in vitro models, updating risk assessment methodology, elaboration of toxicogenomics, chemoinformatics, cellular technologies methods as well as computerized modelling of toxic effects to study modes of action at the cellular and gene levels.

Keywords: toxicology, chemicals, risk


Issues

2018:

Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2017:

Cover of Toxical Review Magazine # 6 '2017 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2017 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 2 '2017 Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 1 '2017 Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2016:

Cover of Toxical Review Magazine # 6 '2016 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2016 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2015:

Cover of Toxical Review Magazine # 6 '2015 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2015 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2015 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2015 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2015 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2015 Jan–Feb: # 1download pdf
 

2014:

Cover of Toxical Review Magazine # 6 '2014 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2014 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2014 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2014 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2014 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2014 Jan–Feb: # 1download pdf
 

2013:

Cover of Toxical Review Magazine # 6 '2013 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2013 Jul–Aug: # 5download pdf / Cover of Toxical Review Magazine # 4 '2013 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2013 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2013 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2013 Jan–Feb: # 1download pdf
 

2012:

Cover of Toxical Review Magazine # 6 '2012 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2012 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2012 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2012 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2012 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2012 Jan–Feb: # 1download pdf
 

2011:

Cover of Toxical Review Magazine # 6 '2011 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2011 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2011 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2011 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2011 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2011 Jan–Feb: # 1download pdf
 

2010:

Cover of Toxical Review Magazine # 6 '2010 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2010 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2010 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2010 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2010 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2010 Jan–Feb: # 1download pdf
 

2009:

Cover of Toxical Review Magazine # 6 '2009 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2009 Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2008:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2007:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2006:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2005:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2004:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2003:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2002:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2001:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2000:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1999:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1998:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu
 

1997:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1996:

Nov–Dec: # 6download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1995:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1994:

Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1993:

May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu


Magazine Founder: FBEPH “Russian Register of Potentially Hazardous Chemical and Biological Substances”