The Journal “Toksikologicheskiy vestnik” (Toxicological Review)

pdf
Download PDF-version file for magazine # 3 '2013.

May–Jun, 2013
# 3


A new look at the toxicometric assessment of acute intoxication with Clozapine
Authors: Lisovik Zh. A. , Ilyashenko K. K. , Rozhkov P. G. , Luzhnikov E. A.

While comparing 48 patients having clinical symptoms of poisoning by Clozapine with its threshold, critical and lethal levels, it was shown that it is necessary not only to take into account an effective concentration of Clozapine in the blood serum but also obligatorily effective concentrations of its pharmacologically active metabolites- Norclozapine and nitrogen-containing oxide.

Keywords:


The state of biological membranes in patients with acute infectious and acute alcohol-based gastroenteritis
Authors: Leventsоva A. Ye. , Makarov V. K.

The study is dedicated to the influence of alcohol and bacterial infection on the state of biological membranes. To determine the membrane state, phospholipids fractions in blood serum were studied as it is known that phospholipids enter into the composition of enterocytes membranes and accordingly any changes in their content in the membrane lead to changes in their content in blood. Parameters of phospholipid fractions in blood serum were studied in 50 healthy people, 50 patients with acute alcohol-based gastroenteritis and 50 patients with acute infectious gastroenteritis.

Keywords:


Experimental study of acute toxicity of supermagnetic Fe3O4 nanoparticles and nanocomplex [DNA+Fe3O4]
Authors: , , Yakubovich Ye. I. , Samsonov R. B. , Lavnikevich D. M. , Yevtushenko V. I.

In experiments on mice SHR, acute toxicity of Fe3O4-based nanoparticles and nanocomplex [DNA+Fe3O4] created at RSCRST was determined. Doses 2,4,6,8 and 10 mmol/kg were tested. Investigation results showed a low toxicity of the preparations. 100% death of animals was not observed for either dose. When testing paramagnetics Fe3O4 , a median lethal dose (LD50) was 18.8 mmol/kg for females and 30 mmol/kg for males. [DNA+Fe3O4] tested, LD50 was 11.2 mmol/kg for females and 11.5 mmol/kg for males.

Keywords:


The effect of chronic intoxication with acetonitrile on parameters of immunity and content of immunoregulatory, pro-inflammatory and anti-inflammatory cytokines in blood
Authors: Zabrodskiy P. F. , Gromov M. S. ,

It was established in experiments on non-inbred rats that chronic intoxication with acetonitrile (30 days, daily subcutaneous 0.05 LD50) equally reduces immune responses associated with the function of Th1-, Th2-and B-lymphocytes, decreases activity of natural killer-cells, antibody-dependent cell-mediated cytotoxicity and reduces levels of immunoregulatory, pro-inflammatory and anti-inflammatory cytokines IFN- , IL-2, IL-4, IL-6, IL-10 and IL-13 in blood.

Keywords:


Suspended substances in the air and donozological changes in children in industrial towns
Authors: Namazbayeva Z. I. , Bazelyuk L. T. , Eshmagambetova A. B. , Pudovk A. M.

Results on accumulation of chemical elements in dust fractions PM 2,5, PM 10 were obtained. A significantly exceeded MAC value of chemicals in the dust composition compared to the concentration of the dust itself was established. Results were received of cytomorphological investigations of cells in the mucous membrane of the nasal cavity and in the cheek buccal epithelium in 108 children of preschool age and in 89 children of school age living n industrial towns, control group was of 60 people. It was noted that nasal and buccal epitheliocytes are sensitive to different exogenous and endogenic exposures of ecofactors which leads to functional changes in those cells where different local disturbances are observed.

Keywords:


Gas Chromatography-Mass Spectrometry Study of Toxicological Profiles of Blister Agents
Authors: Koryagina N. L. , , Ukolova E. S. , Ukolov A. I. , Khlebnikova N. S. , Voitenko N. G. , Radilov A. S.

The excretion profiles of biomarkers of blister agents after intoxication of rats by lewisite and piryte- lewisite mixture at a dose of 1.6 mg/kg were studied. The possibility of determination of lewisite markers in the organism after antidotal therapy with unithiol was assessed. It was found out that the excretion of 2-chlorovinylarsonous acid (CVAA) the first two days after unithiol treatment develops more actively as compared with that in the absence of antidotal therapy. It was shown that the most reliable biomarker to establish a retrospective exposure of an organism to sulfur mustard-lewisite mixtures is CVAA which was detected with confidence in urine 77 days after exposure, while sulfur mustard metabolites such as thiodiglycol, thiodiglycol sulfoxide, and -lyase metabolites, could not be detected by existing procedures even 7 days after exposure.

Keywords:


Monitoring of new phenyl ethylamine derivatives used by the Khanty-Mansiisk Autonomous Area -Yugra population for non-medical purposes
Authors: Nekhoroshev S. V. , Sharko S. P. , Shevyrin V. A.

As a result of a monitoring study of a range of psychoactive substances used by the Khanty-Mansiisk Autonomous Area-Yugra population for non-medical purposes, 18 new phenyl ethylamine derivatives were revealed including Methylone Mephedrone, MDPV, 3-FMC, Butylone, 2С-С, 4-МЕС, PVP, MPPP, Pentylone, Pentedrone, Methedrone, 2C-E, 2C-I 2C-B, PMMA, MDPBP and pFA. Mass-spectrums and chromatographic retention linear indices were obtained for the identified substances.

Keywords:


Evaluation of toxicity of technological additives and designed to intensify grinding for fish
Authors: Fedotov A. S.

Toxicity of technological additives «Litoplast 1AI» and «Litoplast 2AI» for grinding intensification was evaluated on fish standard test-objects: one-day guppy baby-fish (Poecillia reticulate Peters) and one of the year carp (Cyprinus carpio L.). To assess toxic effect on fish, indicators of median lethal concentrations (LC50) characterizing survival changes ( death) by 50% for a determined time period-96 h ( LC50/96h) were applied. Based on evaluation results of the preparations toxicity, it was established that grinding intensifications technological additives «Litoplast 1AI» and «Litoplast 2AI» refer to very slight toxic substances.

Keywords:


Some indicators of the immune and physiological status of roach back (Leuciscus cephalus) inhabiting Caucasus rivers
Authors: Silkina N. I. , Mikryakov V. R. , Mikryakov D. V.

Results of a comparative study on immune and physiological indicators in Caucasus roach back Leuciscus cephalus inhabiting Caucasus rivers are presented. The study is based on the analysis of antimicrobial properties of blood serum, content of non-specific immune complexes and somatic indices of immunocompetent organs. Fishes in the river Mzymty differed from those in Abkhazia rivers in increased somatic indicators of immunocompetent organs, functional state of humoral immune factors, high share of immunodeficiency in individual fishes.

Keywords:


Issues

2018:

May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2017:

Cover of Toxical Review Magazine # 6 '2017 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2017 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 2 '2017 Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Cover of Toxical Review Magazine # 1 '2017 Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2016:

Cover of Toxical Review Magazine # 6 '2016 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2016 Sep–Oct: # 5 У вас нет прав на получение pdf-версии этого номера / Jul–Aug: # 4 У вас нет прав на получение pdf-версии этого номера / May–Jun: # 3 У вас нет прав на получение pdf-версии этого номера / Mar–Apr: # 2 У вас нет прав на получение pdf-версии этого номера / Jan–Feb: # 1 У вас нет прав на получение pdf-версии этого номера
 

2015:

Cover of Toxical Review Magazine # 6 '2015 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2015 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2015 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2015 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2015 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2015 Jan–Feb: # 1download pdf
 

2014:

Cover of Toxical Review Magazine # 6 '2014 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2014 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2014 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2014 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2014 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2014 Jan–Feb: # 1download pdf
 

2013:

Cover of Toxical Review Magazine # 6 '2013 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2013 Jul–Aug: # 5download pdf / Cover of Toxical Review Magazine # 4 '2013 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2013 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2013 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2013 Jan–Feb: # 1download pdf
 

2012:

Cover of Toxical Review Magazine # 6 '2012 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2012 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2012 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2012 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2012 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2012 Jan–Feb: # 1download pdf
 

2011:

Cover of Toxical Review Magazine # 6 '2011 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2011 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2011 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2011 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2011 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2011 Jan–Feb: # 1download pdf
 

2010:

Cover of Toxical Review Magazine # 6 '2010 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2010 Sep–Oct: # 5download pdf / Cover of Toxical Review Magazine # 4 '2010 Jul–Aug: # 4download pdf / Cover of Toxical Review Magazine # 3 '2010 May–Jun: # 3download pdf / Cover of Toxical Review Magazine # 2 '2010 Mar–Apr: # 2download pdf / Cover of Toxical Review Magazine # 1 '2010 Jan–Feb: # 1download pdf
 

2009:

Cover of Toxical Review Magazine # 6 '2009 Nov–Dec: # 6download pdf / Cover of Toxical Review Magazine # 5 '2009 Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2008:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2007:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2006:

Nov–Dec: # 6download pdf / Sep–Oct: # 5download pdf / Jul–Aug: # 4download pdf / May–Jun: # 3download pdf / Mar–Apr: # 2download pdf / Jan–Feb: # 1download pdf
 

2005:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2004:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2003:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2002:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2001:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

2000:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1999:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1998:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu
 

1997:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1996:

Nov–Dec: # 6download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1995:

Nov–Dec: # 6download djvu / Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1994:

Sep–Oct: # 5download djvu / Jul–Aug: # 4download djvu / May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu
 

1993:

May–Jun: # 3download djvu / Mar–Apr: # 2download djvu / Jan–Feb: # 1download djvu


Magazine Founder: FBEPH “Russian Register of Potentially Hazardous Chemical and Biological Substances”