The Journal “Toksikologicheskiy vestnik” (Toxicological Review)
At the sub-chronic intra-abdominal priming of rats with sub-lethal doses of sodium fluoride and lead acetate it was shown that a combined toxic action of these substances is additive and sub-additive based on a number of effects. Particularly, the influence of fluorine increases an adverse impact of lead on the porphyria metabolism and lead-induced augmentation of the reticulocytes number in blood; and only a combination of fluorine and lead induces a significant lowering of the thyrotropic hormoneleve and others. At the background of the administration of the complex having in its composition bio protectors acting on toxico-dynamic and toxicokinetic intoxication mechanisms ( pectin, sodium glutamate, preparations (Complivite Active and Complivite Calcium D3 ), a weakening of a number of effects of the combined adverse action was noted.
A study was conducted on a polyvalent sensibilization to occupational toxic substances having an expressed allergenic effect, as well as on the problem of assessment of working conditions classes basing on a leading allergizing factor-allergen. The issu of regulating occupational allergens in the occupational air was considered.
A methodology of assessing an alcohol situation is proposed to determine the alcohol-consuming population group at risk and to assess the extent of this risk factor among the large population in the region. The outcome of the alcohol situation monitoring and prophylactic measures based on the information generated allows to get aware of the significance of the alcohol factor as integral hazard to human health. Thus, it will contribute to the solution of hygienic issues related to the population’s chemical safety in the region.
Sodium dithionite manifests to a greater extent detoxification properties at an acute poisoning of rats by ethanol than sodium metabisulfite and unitiol. Effects of the preparation are linked to a significant decrease of ethanol oxidation products, ethanol anti-oxidation and secondary cyto-protective action on hepatocytes membrane structures.
The present article is dedicated to the assessment of detoxification effects of interosseal lymphotropic injections (IOLI), lymphotropic sorption and lymphotropic ozone technics in pathogenesis of acute and sub-acute stages of the opioid withdrawal status. 201 patients were distributed in to 4 homogenons groups. The comparison group received a standard therapy; the main first group was treated with IOLI in addition to the standard treatment, the second main one was treated with the IOLI complex and enterosorption, the third was treated with the IOLI complex and ozone therapy. Patients were examined on the 2nd and 8th days of the treatment. It was shown that when using a standard therapy, the desinhibition of detoxification processes in the organism acquires a pathogenetic significance which in combination with overexertion of renal and immune parts of the natural detoxification system leads to the generalization of endotoxicosis and disturbances in the recovery process. The IOLI detoxification effect was confirmed by the restriction of the pathogenetic significance of the endogenic intoxication syndrome and preservation of the functional reserve of the organism natural detoxification system. The lymphotropic sorption and lymphotropic ozonic technics ensured a substantial enhancement of the organism detoxification in pathogenetic and non-specific directions and accelerated the convalescence process by repairing the barrier filtration function and stimulating the immune function of the lymphatic system.
A comparative characterization was conducted of the efficiency of intestinal lavage itself and in combination with enterosorption for the body detoxification at acute peroral poisonings by psychopharmacological means. It was shown that the use of a saline enteral solution, which ionic composition is identical to that of the human small intestine chyme, to lavage gastrointestinal tract does not lower sorption properties of enterosorbents if combined. At poisoning by psychopharmacological means, enterosorption in combination with intestinal lavage increases the efficacy of the latter by 20 to 30%.
The article presents a comparative evaluation of the incidence of cytogenetic disorders in children ( based on micronucleas testing in the buccal epithelium) in the Bryansk region ecologically unfavorable territories with a different density of the toxic (from1.7 to 171.6 kg/head /year for toxicological substances), radioactive ( from 10.7 to 504.3 kBc/m2 as 137 Cs) and combined pollution of the environment. Statistically authentic advers changes in the cytogenetic status in children were established under conditions of a high-toxic, confined -radiation and especially toxic-radiation pollution of the environment which manifested in an increased frequency of binucleated cells and cells with karyopyknosis and karyolysis.
Based on experimental and clinical data, the distribution of mercury between blood erythrocytes and plasma in rats and humans was investigated. The top reference limit value of the mercury concentration in the human whole blood equal to 7 mkg/dm3 was substantiated.
The outcome of the determination of the Maximum tolerance dose (MTD) did not show any authentic differences between Zrv-IIA and Zrv-IIB. Based on investigation results, Zervamicin can be referred to toxicity class 2 (2>LD50>20 mg/kg for mice CD-1). The peptidic antibiotic Arenicin unlike Zervamicins could be allocated to toxicity class 3 ( 20>LD50>700 mg/kg for mice CD-1). The peptidic antibiotic Aurelin manifests an expressed toxic picture at a dose of 75 mg/kg followed by the death of the laboratory animal. However, the death was not noted at the dose of 50 mg/kg which allows to presumably allocate the peptidic antibiotic investigated to toxicity class 3 for mice CD-1.
Methodology of isolating Metamizole in urine, its identification and quantitative evaluation was developed using chemical (chromogenic and microcrystalloscopic reactions) and physico-chemical methods (thin layer chromatography and high effective liquid chromatography methods. A complex use of the said methodology allows to authentically diagnose a poisoning by Metamizole used separately or jointly with other analgecics.